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Preclinical Efficacy Testing

Aragen Bioscience biologists ably guide customers through preclinical in vitro and in vivo testing, recommending appropriate cell based assays and animal models. With a broad range of established working models, we also develop customized assays and in vivo models relevant for the diverse biology involved in finding answers and cures in multiple therapeutic areas.

60+

cancer cell lines

50+

validated animal models of disease

12+

clients advanced to Phase II

Fibrosis

Aragen Bioscience has a portfolio of in vivo fibrosis models and world class expertise to support clients in the development of anti-fibrotic therapeutic or prophylactic candidates

  • Lung Fibrosis Model in C57BL/6 Mice
  • Lung Fibrosis Model – Aged Mice<
  • Silica-Induced Lung Fibrosis Model in Mice
  • Dermal Fibrosis in a Scleroderma Mouse Model
  • Renal Interstitial Fibrosis Model: Unilateral Ureteral Obstruction (UUO) in Mice
  • CCL4 Induced Liver Fibrosis Model in Mice
  • TAA Induced Liver Fibrosis Model in Rats
  • CDAHFD Model of Non-Alcoholic Steatohepatitis (NASH) Model
  • Diet-Induced Non-Alcoholic Steatohepatitis (NASH) Model in Mice
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Fibrosis

Aragen Bioscience has a portfolio of in vivo fibrosis models and world class expertise to support clients in the development of anti-fibrotic therapeutic or prophylactic candidates

  • Lung Fibrosis Model in C57BL/6 Mice
  • Lung Fibrosis Model – Aged Mice<
  • Silica-Induced Lung Fibrosis Model in Mice
  • Dermal Fibrosis in a Scleroderma Mouse Model
  • Renal Interstitial Fibrosis Model: Unilateral Ureteral Obstruction (UUO) in Mice
  • CCL4 Induced Liver Fibrosis Model in Mice
  • TAA Induced Liver Fibrosis Model in Rats
  • CDAHFD Model of Non-Alcoholic Steatohepatitis (NASH) Model
  • Diet-Induced Non-Alcoholic Steatohepatitis (NASH) Model in Mice
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Oncology

Aragen Bioscience offers a diverse range of preclinical oncology models and services with client-specific customized study design. These include human xenograft tumor models as well as the more complex sub-renal capsule, patient-derived xenograft (PDX), and syngeneic tumor models

  • Xenograft Models >100 models
  • Syngeneic   >20 models
  • Immuno Oncology (IO) Models
  • Custom Tumor Models
  • Non-Invasive Imaging
  • Bio-analysis & PK-PD Correlation
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Oncology

Aragen Bioscience offers a diverse range of preclinical oncology models and services with client-specific customized study design. These include human xenograft tumor models as well as the more complex sub-renal capsule, patient-derived xenograft (PDX), and syngeneic tumor models

  • Xenograft Models >100 models
  • Syngeneic   >20 models
  • Immuno Oncology (IO) Models
  • Custom Tumor Models
  • Non-Invasive Imaging
  • Bio-analysis & PK-PD Correlation
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Immunology and In Vitro Pharmacology

Our preclinical research in immunology and inflammation focuses on arthritis and autoimmunity. Strong collaborations with various academic, governmental, and industrial laboratories have enabled the development of several experimental models of immunology and inflammatory diseases

  • Inflammatory Fibrosis
  • Colon Inflammation
  • Dermal Inflammation
  • Multiple Sclerosis
  • Inflammatory Arthritis
  • Inflammatory Bowel Disease
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Immunology and In Vitro Pharmacology

Our preclinical research in immunology and inflammation focuses on arthritis and autoimmunity. Strong collaborations with various academic, governmental, and industrial laboratories have enabled the development of several experimental models of immunology and inflammatory diseases

  • Inflammatory Fibrosis
  • Colon Inflammation
  • Dermal Inflammation
  • Multiple Sclerosis
  • Inflammatory Arthritis
  • Inflammatory Bowel Disease
Read More

Infectious Diseases

Aragen Bioscience’s expertise in a number of infectious disease models, along with its diverse portfolio of ex-vivo analyses makes us an ideal partner for discovery and pre-clinical evaluation of your candidates

  • Respiratory syncytial virus (RSV) in mice and cotton rats
  • Mouse cytomegalovirus (mCMV)
  • Clostridium difficile-associated diarrhea model in hamsters and mice
  • Influenza and Human Metapneumovirus mouse models
  • Mouse coronavirus MV-A59
  • Citrobacter-induced colitis in mice
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Infectious Diseases

Aragen Bioscience’s expertise in a number of infectious disease models, along with its diverse portfolio of ex-vivo analyses makes us an ideal partner for discovery and pre-clinical evaluation of your candidates

  • Respiratory syncytial virus (RSV) in mice and cotton rats
  • Mouse cytomegalovirus (mCMV)
  • Clostridium difficile-associated diarrhea model in hamsters and mice
  • Influenza and Human Metapneumovirus mouse models
  • Mouse coronavirus MV-A59
  • Citrobacter-induced colitis in mice
Read More

Respiratory Diseases

Aragen Bioscience provides preclinical RSV therapeutic development studies by providing appropriate study designs, right animal models, and confirming effective immune response by performing in vivo and in vitro assays

  • Respiratory syncytial virus (RSV)
  • Influenza and Human Metapneumovirus mouse models
  • Mouse coronavirus MV-A59
Read More

Respiratory Diseases

Aragen Bioscience provides preclinical RSV therapeutic development studies by providing appropriate study designs, right animal models, and confirming effective immune response by performing in vivo and in vitro assays

  • Respiratory syncytial virus (RSV)
  • Influenza and Human Metapneumovirus mouse models
  • Mouse coronavirus MV-A59
Read More

Histology and Digital Pathology

Digital histology services refer to the use of digital technology to capture, analyze, store, and share histological (microscopic) images of tissues and cells.

  • Digital Histology
  • Digital Pathology
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Histology and Digital Pathology

Digital histology services refer to the use of digital technology to capture, analyze, store, and share histological (microscopic) images of tissues and cells.

  • Digital Histology
  • Digital Pathology
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